However, when President Garfield was assassinated, Blaine was removed from his post and the process for creating the Pan-American Conference was slowed down.

Another reason for this union was for the United States to be financially benefited from the other countries – this is an aspect that the other countries soon realized, and through the conferences, attempted to prevent this from occurring. Blaine determined that if the United States were to be the country that put forward the idea of a Union of the Americas, the United States would hold the upper hand and would be able to guide the agenda as well as carry heavy weight in major decision-makings. In an attempt to solidify the idea of the 'Western Hemisphere', Secretary of State James. This unofficial union of the countries that comprised North, Central and South America would allow for relationships to slowly develop between the countries. This doctrine was set in place in order to ensure that the colonies that were currently in place (and independent) would remain that way and to ensure that the Americas would be able to remain independent of each other and yet bond each other together at the same time.

In this speech, President Monroe stated that any further attempts by the Europeans to colonize the Americas (North, Central and South) would be seen as an act of aggression and would risk intervention by the United States. Blaine to push for the creation of the Pan-American Conferences. On 2 December 1823, President James Monroe delivered the ' Monroe Doctrine' which would eventually influence Secretary of State James G. Blaine hoped that ties between the United States and its southern counterparts would open Latin American markets to US trade. Blaine, a United States politician, Secretary of State and presidential contender, first proposed establishment of closer ties between the United States and its southern neighbors and proposed international conference. The Conferences of American States, commonly referred to as the Pan-American Conferences, were meetings of the Pan-American Union, an international organization for cooperation on trade. 1906 Pan-American Conference, Rio de Janeiro

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